Flavan-3-ol Biosynthesis

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Purification of flavan-3-ol biosynthesis for co-localization onto nanocarriers and a multi-enzyme assay

Flavonoids are polyphenolic secondary metabolites that serve a variety of purposes, from assisting pollination in plants to providing anti-cancerous activity in humans. It is the wide range of functions that give these molecules the highly revered status they have today. Range in function can be linked with the range in structure, and with over 10,000 different flavonoids known, they make up on...

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Antioxidative flavan-3-ol glycosides from stems of Rhizophora stylosa.

Two flavan-3-ol glycosides together with seven flavan-3-ols were isolated from stems of the mangrove plant, Rhizophora stylosa. Their structures were established as glabraoside A (7) and glabraoside B (8) by spectroscopic and chemical methods. The antioxidative activity of these isolated compounds evaluated by the diphenylpicrylhydrazyl (DPPH) radical scavenging reaction was higher than that of...

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(-)-Catechin in cocoa and chocolate: occurrence and analysis of an atypical flavan-3-ol enantiomer.

Cocoa contains high levels of different flavonoids. In the present study, the enantioseparation of catechin and epicatechin in cocoa and cocoa products by chiral capillary electrophoresis (CCE) was performed. A baseline separation of the catechin and epicatechin enantiomers was achieved by using 0.1 mol x L(-1) borate buffer (pH 8.5) with 12 mmol x L(-1) (2-hydroxypropyl)-gamma-cyclodextrin as ...

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Efficacy of prophylactic flavan-3-ol in permanent focal ischemia in 12-mo-old mice.

The consumption of flavan-3-ol-containing foods, including (-)-epicatechin (EC), has been linked to lower incidence of cardiovascular disease and stroke. We previously demonstrated nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) -dependent EC efficacy in reducing stroke-induced deficits in 2-mo-old mice; yet stroke is primarily a disease of the elderly. Because neuroinflamma...

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Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors.

We herein describe the synthesis and positive modulatory activities of a small library of flavan-3-ol derivatives on alpha(1)beta(2)gamma(2L) GABA(A) receptors. Structure-activity relationships of various substituents on the A, B and C rings were evaluated in a functional electrophysiological assay. A trans configuration and a 3-acetoxy moiety are essential for activity. Substitution of the B r...

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ژورنال

عنوان ژورنال: Plant Physiology

سال: 1984

ISSN: 0032-0889,1532-2548

DOI: 10.1104/pp.76.1.184